We study the molecular mechanisms of neurodegeneration in the fruit fly. Perhaps surprisingly, the molecular pathways between flies and humans are very similar, making it a great organism in which to model MND.

Dr Giuseppa Pennetta

Centre for Integrative Physiology

Email: g.pennetta@ed.ac.uk

I am a molecular geneticist. The major focus of my research is the study of the molecular mechanisms underlying the pathogenesis of MND, using the fruit-fly Drosophila melanogaster as a model organism. The high degree of similarity in genetic function and molecular pathways between Drosophila and humans has made this organism an extremely versatile model for the study of human biology and neurodegeneration in particular. We generated a fly model for motor neurone disease and we are currently using it to elucidate the mechanisms of this devastating disease. We are confident that this approach will lead to the identification of potential new targets for effective therapeutic interventions.

Full Profile: http://www.ed.ac.uk/schools-departments/integrative-physiology/staff-profiles/guisy-pennetta