Professor of Molecular Neurobiology, Centre for Integrative Physiology, University of Edinburgh
Ca2+ signaling pathways to degeneration or resilience in the neuroglial unit
Prof. Hardingham’s laboratory is focussed in the molecular mechanisms of core interdependent pathological processes upon which several neurological disorders, including MND converge, including oxidative stress, mitochondrial dysfunction, inflammation, and aberrant NMDA receptor activity. He is also interested in the brain’s capacity for homeostasis, particularly the ability of neurons and astrocytes to mount adaptive protective responses to adverse conditions, through both inter- and intra-cellular signaling between different cell types in the brain. Knowledge of both neurodegenerative pathways and neuroprotective ones can reveal therapeutic targets for neurodegenerative disorders.