Dr Mark Bastin

Richard Davenport

Biography

Dr. Bastin graduated from the Universities of York, Edinburgh and Oxford with degrees in Theoretical Physics (BSc (Hons)), Remote Sensing and Image Processing Technology (MSc) and Geophysical Fluid Dynamic (DPhil). He then pursued a long held interest in medical imaging and magnetic resonance techniques by joining Professor George Radda's magnetic resonance spectroscopy (MRS) unit in the Dept. of Biochemistry, University of Oxford, where he worked on skin and cardiac MRS methods for 4 years. He then moved to Edinburgh to work on magnetic resonance imaging (MRI) of the brain as a research associate in the Dept. of Medical Physics and SFC Brain Imaging Research Centre. After 12 months in this post, he was appointed lecturer in MRI in 1998. In 2006, he was appointed Reader in Brain Imaging.

Research Overview

Dr. Bastin's primary research interest is in the development of MRI acquisition methods and image processing techniques and their application to the study of the pathophysiology of diseases of the brain. Specific areas of interest include:
  • Diffusion MRI and tractography
  • Dynamic susceptibility contrast perfusion MRI
  • Magnetization transfer MRI
  • Quantitative spin-lattice relaxation (T1) measurement
  • Application to stroke, normal ageing, brain tumours, MND, MS, schizophrenia and bipolar disorder.
He has authored over 80 articles in leading peer-review journals. He currently supervises or co-supervises six PhD students and is the principal investigator or co-applicant on approximately £7M of grant funding.

Qualifications

  • D.Phil. Geophysical Fluid Dynamics, Department of Atmospheric Physics, Clarendon Laboratory, University of Oxford, 1993
  • M.Sc. Remote Sensing and Image Processing Technology, Department of Meteorology, University of Edinburgh, 1989
  • B.Sc. (Hons.) Theoretical Physics, Department of Physics, University of York, 1988


Select Publications

Walter T, Shattuck DW, Baldock R, Bastin ME, Carpenter AE, Duce S, Ellenberg J, Fraser A, Hamilton N, Pieper S, Ragan MA, Schneider JE, Tomancak P, Hériché JK. Visualization of image data from cells to organisms. Nature Methods 2010;7(3):S26-41.

Bastin ME, Muñoz Maniega S, Ferguson KJ, Brown LJ, Wardlaw JM, MacLullich AM, Clayden JD. Quantifying the Effects of Normal Ageing on White Matter Structure using Unsupervised Tract Shape Modelling. NeuroImage 2010;51(1):1-10.

Shenkin SD, Bastin ME, MacGillivray TJ, Eadie E, Deary IJ, Starr JM, Wardlaw JM. Carotid intima-media thickness and cerebrovascular disease in community-dwelling older people without stroke. Stroke 2010;41(9):2083-2086.

Bastin ME, Clayden JD, Pattie A, Gerrish IF, Wardlaw JM, Deary IJ. Diffusion tensor and magnetization transfer MRI measurements of periventricular white matter hyperintensities in old age. Neurobiology of Aging 2009;30(1):125-136.

Bastin ME, Piatkowski JP, Storkey AJ, Brown LJ, MacLullich AM, Clayden JD. Tract Shape Modelling Provides Evidence of Topological Change in Corpus Callosum Genu During Normal Ageing. NeuroImage 2008;43(1):20-28.