Institute for Genetics and Molecular Medicine
We are investigating the role of RNA editing and glutamate excitoxicity in ALS and other neurodegenerative diseases. RNA editing of transcripts encoding ionotropic glutamate receptor subunits controls many aspects of AMPA and kainate receptor function. Reduced RNA editing of the Q/R editing site in the GluR-B transcript leads to increased calcium permeability of AMPA receptors and has been reported in motor neurones in Japanese sporadic ALS patients.
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