Euan MacDonald Centre Investigator Prof Tom Gillingwater is part of a European Consortium that has just been awarded a 2.5M Euro research grant to investigate the molecular workings of motor neurons.
The project, called “AXONOMIX – identifying the translational networks altered in motor neuron diseases”, will be undertaken by researchers in Edinburgh and four Italian labs.
The project will merge classical cell biology with state-of-the-art imaging and molecular analysis technologies coupled to sophisticated bioinformatics. It aims to provide a comprehensive map of the particular sets of proteins that are made within the various subregions of motor neurons, both in healthy cells and those derived from models of MND. An understanding of the protein changes that might underlie neurodegeneration could lead to new drug targets or indicate small molecules that could restore the normal protein balance.