Cellular energy-processing pathways regulate degeneration in SMA

Euan MacDonald Centre researchers have shown how energy levels in neurons regulate degeneration in models of spinal muscular atrophy.

The Gillingwater, Becker and Wishart labs, working in collaboration with colleagues from the University of Edinburgh and the University of Sheffield, have published a new paper showing that motor neurons can be protected in mouse and fish models of the childhood motor neuron disease spinal muscular atrophy (SMA) by targeting energy-processing pathways.

The paper has been published in PLoS Genetics and is free to download: Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy

Congratulations to the researchers on the excellent outcome of this collaboration.